treatment of malignant tumors

Malignant Melanoma Treatment & Management

Surgery is the definitive treatment for early­stage melanoma. Wide local excision with sentinel lymph
node biopsy and/or elective lymph node dissection (LND) is considered the mainstay of treatment for
patients with primary melanoma. In patients with solitary or acutely symptomatic brain metastases,
surgical management may alleviate symptoms and provide local control of disease. [24]
Because the definitive treatment of cutaneous melanoma is surgery, medical management is reserved
for adjuvant therapy of patients with advanced melanoma. Less than one half of patients with deep
primaries (>4 mm) or regional lymph node involvement have long­term disease­free survival;
consequently, these patients are classified as high risk and should be considered for adjuvant therapy.
Interferon alfa is approved for adjuvant treatment after excision in patients who are free of disease but are at high risk for recurrence. Currently, there are no standard systemic therapeutic regimens that
offer significant prolongation of survival for most patients with metastatic melanoma without significant
risk of toxicities.In patients with BRAF V600 wild­type unresectable or metastatic melanoma, however,
the introduction of immune­based therapy has resulted in improved survival.
Also see Lentigo Maligna Melanoma, Oral Malignant Melanoma, and Head and Neck Mucosal
Melanomas.

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Download this document Modern Surgical Treatment of Malignant Skin Melanoma

The study established that the most modern surgicaltreatment of a malignant melanoma of the skin includes:primary tumour biopsy, sentinel biopsy of the regionallymph nodes with wide re-excision of the affected area,usually with a radius of 2cm, and the removal of localrecurrences, lymph and distant organ metastases. When itcomes to monitoring, it has to be done according to thecontemporary worldwide guidelines.

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